Growth phase‐dependent changes in the size and infectivity of SDS‐resistant Sup35p assemblies associated with the [PSI+] prion in yeast

What is it about?

Self-replicating Sup35p aggregates are responsible for the [PSI⁺] prion state in yeast and often monitored by the detection of detergent-resistant Sup35p assemblies on agarose gels under semi-denaturant conditions. Here, we report dramatic growth phase-dependent changes in the size and amounts of SDS-resistant Sup35p and show that these do not correlate with infectivity.

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