The trans-envelope architecture and function of the type 2 secretion system: new insights raising new questions

What is it about?

The type 2 secretion system promotes secretion of fully folded and active enzymes or toxins from the periplasm to the surface of Gram-negative bacteria. We describe recent insights into the architecture of this molecular machine and our current understanding of how it recognizes, takes up and secretes specific proteins across the bacterial envelope.

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