Transcriptional regulation of adhesive properties ofBacillus subtilisto extracellular matrix proteins through the fibronectin-binding protein YloA

What is it about?

Bacterial adherence to extracellular matrix proteins plays important roles during host-pathogen interaction, however its genetic regulation remains poorly understood. Here, we characterized the YloA-dependent adhesive- and biofilm-formation properties of the probiotic bacterium Bacillus subtilis and its regulatory network. The transcription factors AbrB and DegU downregulated yloA expression. Interestingly, B. subtilis bound fibronectin with higher affinity than several pathogens and competitively excluded them from binding, reinforcing the view of the anti-infective properties of this probiotic bacterium.

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