Insulation and wiring specificity of BceR-like response regulators and their target promoters inBacillus subtilis

What is it about?

An efficient insulation is essential to ensure wiring specificity of highly similar signal transducing systems. Here, we describe the regulatory features necessary to allow discrimination of two target promoters by their corresponding paralogous response regulators, involved in mediating resistance against antimicrobial peptides in Bacillus subtilis. We demonstrate that regulator competition in combination with hierarchical cooperative binding ensures specificity despite only slight differences in binding affinities.

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