What is it about?
Expression of over 100 molecules associated with inflammation or immune activation was evaluated in mesenteric lymph nodes and ileum of macaques infected with a pathogenic SIV/HIV virus, RT-SHIV, during viremia or during suppressive ART and compared to uninfected controls. Expression of 33 genes was altered significantly in one or both tissues during viremia but returned to normal levels during ART. However, 29 other genes were altered in expression levels in the tissues of both viremic and ART-suppressed macaques.
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Why is it important?
Identification of the mechanisms of chronic inflammation in specific cells and in different tissues may help determine whether early ART initiation or novel therapies can prevent it.
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This page is a summary of: Dysregulation of multiple inflammatory molecules in lymph node and ileum of macaques during RT-SHIV infection with or without antiretroviral therapy, Journal of Medical Primatology, May 2014, Wiley,
DOI: 10.1111/jmp.12126.
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