What is it about?
Olfactory Ensheathing Cells (OECs) are able to exert neuroprotective and regenerative action. Herein we demonstrate that OECs conditioned medium reduce Cx43-mediated cell-to-cell and cell-to-extracellular environment communication and that selective inhibition of Cx43 gap junctions and hemichannels allow to overcome stress conditions.
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Why is it important?
This work support the hypothesis that Cx43 play a role in the regulation of tissue homeostasis, spreading neurodegenerative signals and represents a druggable target for neuroprotective approaches.
Perspectives
This paper uncover a novel mechanism of action mediated by OECs conditioned medium, which acts reducing the expression levels of Cx43. Further investigations are likely to confirm in vitro and in vivo the involved molecular mechanisms in experimental model of neurodegenerative disorders.
Professor Nunzio Vicario
Read the Original
This page is a summary of: Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells, Journal of Cellular and Molecular Medicine, May 2017, Wiley,
DOI: 10.1111/jcmm.13177.
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