What is it about?
Several self-antigens such as Insulin, glutamic acid decarboxylase (GAD) or IA-2 have been reported as targets of the autoimmune response in nonobese diabetic (NOD) mice. The aim of this study was to identify autoantibody assays that could provide useful biomarkers of autoimmunity in nonobese diabetic (NOD) mouse model for type 1 diabetes.
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Why is it important?
This study has demonstrated that anti-insulin antibody measured by sensitive radioimmunoassay indicated that insulin is a strong biomarker of autoimmunity in NOD mice and draw into question the true nature of anti-GAD and anti-IA-2 antibodies as marker of disease in NOD mouse model of type 1 diabetes.
Perspectives
This study has demonstrated that anti-insulin antibody measured by sensitive radioimmunoassay indicated that insulin is a strong biomarker of autoimmunity in NOD mice and draw into question the true nature of anti-GAD and anti-IA-2 antibodies as marker of disease in NOD mouse model of type 1 diabetes.
Dr Bhagirath Singh
Western University
Read the Original
This page is a summary of: International Workshop on Lessons from Animal Models for Human Type 1 Diabetes, Annals of the New York Academy of Sciences, January 2006, Wiley,
DOI: 10.1111/j.1749-6632.2002.tb02941.x.
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