What is it about?
Nitric oxide (NO) releasing drugs are a novel class of effective and safe agents for cervical ripening. We have used isosorbide dinitrate donor to induce cervical ripening of women with missed abortions before surgical evacuation of the uterus.
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Why is it important?
The NO donor, isosorbide mononitrate, is effective at inducing cer-vical ripening during the first trimester, prior to medical termination of pregnancy. Two significant findings are that: 1) intracervical administration of 80 mg isosorbide dinitrate in women with missed abortions appears to be effective than misoprostol for cervical ripening prior to surgical evacuation of the uterus, and 2) we identify differences in the incidence of non‐serious adverse events are not likely to be clinically significant.
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This page is a summary of: Intracervical application of the nitric oxide donor isosorbide dinitrate for induction of cervical ripening: a randomised controlled trial to determine clinical efficacy and safety prior to first trimester surgical evacuation of retained products of co..., BJOG An International Journal of Obstetrics & Gynaecology, December 2005, Wiley,
DOI: 10.1111/j.1471-0528.2005.00760.x.
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