What is it about?
No DNA synthesis occurs in dnaA recA double mutant at high temperature after gamma ray irradiation.In dnaA mutant DNA replication does not start at non permissive temperature. A small dose of gamma ray irradiation allows the mutant to reinitiate the replication. The process is dependent on RecA suggesting a participation of SOS induction.
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Why is it important?
Probably the Double Stand Breaks repair process reinitiates DNA replication in dnaA mutant since the phenomenon depends on RecA and RecB.The importance of SOS induction in the process is suggeqted.
Perspectives
The question is how the replicative helicase is loaded on chromosome in the absence od DnaA after gamma ray irradiation.
Dr masamichi kohiyama
Universite Paris deiderot; Inst.J.MOnod
Read the Original
This page is a summary of: Gamma-Ray Induction of Deoxyribonucleic Acid Synthesis in Temperature-Sensitive DNA Initiation Mutants of Escherichia coli, European Journal of Biochemistry, May 1983, Wiley,
DOI: 10.1111/j.1432-1033.1983.tb07378.x.
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