What is it about?
Previous work has demonstrated that bile salts induce the ability of Shigella flexneri to adhere and invade epithelial cells. This work demonstrates that the induced adherence phenotype is mediated by the virulence proteins OspE1 and OspE2 binding to the bacterial outer membrane following bile salts exposure.
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Why is it important?
This work demonstrates that OspE1 and OspE2 function as adhesins, which represent the first adherence factors to be identified for Shigella flexneri.
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This page is a summary of: Shigella flexneri effectors OspE1 and OspE2 mediate induced adherence to the colonic epithelium following bile salts exposure, Molecular Microbiology, May 2012, Wiley,
DOI: 10.1111/j.1365-2958.2012.08092.x.
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