Treatment of standardised wounds with pure epidermal micrografts generated with an automated device

What is it about?

Pure epithelial skin grafting has been "reinvented" with an automated harvestiung device and may further final healing of wounds

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Why is it important?

Eearlier studies from von Mangold dating from 1876 and in further developing Reverdins fulll thickness Skin particle Transplantation into partially epithelial and partially compound grafts with remnants ofd dermis had been utilized to Close chronic wounds. Ever since - especially ba the Advent of tissue Engineering - epithelial grafts had been used for problematic wounds and more or less were reported anecdotically. As it is with chronic wounds there is a mutlitude of influencing factors which male it difficult to consistently test epithelial grafts. Therefore we used Skin graft donor site wounds since they are standardized by depth and normally heal without significant Problems. We found that epidermal grafts however enhanced wound healing and provided more stable healed woudns when compared to controls. Since there alsmost no donor site side effect after epidermal harvestung it could prove a valuable tool to resurface also problem atic wounds. Although more long term results need to be gained this study shows an effect of epidermal micrografts in a standardised human wound model and supports the positive impact of keratinocytes on early wound healing as described in literature.

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