What is it about?
Nutrients, such as amino acids (AAs), are not only a caloric source, but can also modulate cell metabolism and modify hormone homeostasis. Our hypothesis is that the environmental messages provided by AAs rule the dynamics of cancer cell life or death, and the alteration of the balance between essential amino acids (EAAs) and non-essential amino acids (NEAAs) (lower and higher than 50%, respectively) present in nutrients may represent a key instrument to alter environment-dependent messages, thus mastering cancer cells destiny.
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Why is it important?
Customization of dietary ratios between EAAs and NEAAs by specific AA mixtures may represent a promising anticancer strategy able to selectively induce death of cancer cells
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This page is a summary of: Essential amino acid mixtures drive cancer cells to apoptosis through proteasome inhibition and autophagy activation, FEBS Journal, May 2017, Wiley,
DOI: 10.1111/febs.14081.
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