What is it about?
Antituberculosis drugs can lead to drug interactions and unwanted effects by either increasing or decreasing the activity of drug metabolizing enzymes. CYP2C19 is one such enzyme and the effect of antituberculosis drugs on this enzyme has been studied in this research paper.
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Why is it important?
The change in CYP2C19 activity after ATT intake and how it is related to the genetic make up of the participants, have been tried to explain in the study. It is important to assess the risk of drug interactions in tuberculosis patients.
Read the Original
This page is a summary of: Effect of antituberculosis treatment on CYP2C19 enzyme activity in genetically polymorphic South Indian Tamilian population, Fundamental and Clinical Pharmacology, July 2016, Wiley,
DOI: 10.1111/fcp.12218.
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