What is it about?
We found an incidence of documente fingal infections of 2.5% in patient after chemotherapy or hematopoietic stem cell transplantation. Severe neutropenia was the most frequent risk factor. Candida spp., mostly non-albicans, prevailed among the agents isolated in the blood cultures whereas Aspergillus infection was more often identified by serum galactomannan positivity.
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Why is it important?
About two-thirds of pediatric patients with documented fungal infection survived, regardless of whether the infection occurred after frontline chemotherapy, reinduction chemotherapy for disease relapse, or after HSCT. .
Perspectives
Further prospective studies are needed to define the impact of antifungal prophylaxis and early combination therapy on short-term overall survival
Medical Doctor Simone Cesaro
Read the Original
This page is a summary of: Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients, European Journal Of Haematology, June 2017, Wiley,
DOI: 10.1111/ejh.12910.
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