What is it about?
Antibodies against HLA (called DSA) of the donor often exist before liver transplantation (LT), but can also develop after LT. Non-anastomotic biliary strictures (NAS) often complicate LT. We examined whether pre- and post-LT DSA are related to development of NAS after LT and if DSA were related to survival of the transplanted liver. We demonstrate that pre-LT DSA often disappear, while new DSA often appear after LT. Development of non-anastomotic biliary strictures (NAS) was not related to presence of pre- or post-LT DSA. However both development of NAS and development of post-LT DSA were related to worse survival of the transplanted liver,
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Why is it important?
These data show that DSA play no role in development of non-anastomotic biliary strictures after liver transplantation. It also demonstrates that both development of such biliary strictures and development of DSA after liver transplantation are associated with worse survival of the transplanted liver.
Perspectives
- Other possible risk factors for development of non-anastomotic biliary strictures after liver transplantation have to be identified. - It has to be identified if the relationship of DSA with worse graft survival is by antibody-mediated rejection or by other mechanisms.
Prof. Dr. Bart van Hoek
Universiteit Leiden
Read the Original
This page is a summary of: Donor-specific anti-HLA antibodies are not associated with nonanastomotic biliary strictures but both are independent risk factors for graft loss after liver transplantation, Clinical Transplantation, December 2017, Wiley,
DOI: 10.1111/ctr.13163.
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