What is it about?
This state of the art paper resumes the latest consideration about the analysis of alveolar-capillary diffusing capacity (DLCO) and its constitutive components (membrane conductance Dm and capillary blood volume Vc). The famous Roughton and Forster equation (1957) has been revised. Impact of some physiological terms on the outcome, including ambient oxygen pressure, mean intracapillary oxygen partial pressure, Hb concentration and specific gas conductance (θCO and θNO) has been evaluated
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Why is it important?
By using real and simulated data, the authors showed that: 1. Double-diffusion (TLNO-DLCO) would be considered as the only reliable method for studying Dm and Vc. 2. The values of DmCO and Vc depend critically on the chosen θ value. 3. The calculation should base on a finite value of reaction rate between NO and Hb (θNO). The interpretation of new Dm and Vc values might bring different information
Perspectives
Based upon those statements, conventional algorithm for estimating Dm and Vc by should be reconsidered.
Dr JEAN-BENOIT MARTINOT
Sleep Laboratory, CHU UCL Namur Site Sainte-Elisabeth, Belgium
Read the Original
This page is a summary of: Nitrogen monoxide and carbon monoxide transfer interpretation: state of the art, Clinical Physiology and Functional Imaging, November 2015, Wiley,
DOI: 10.1111/cpf.12316.
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