What is it about?
Anti-insulin antibodies may produce recurrent unexplained hypoglucaemia or hyperglycaemia. However many biochemical labs who offer anti-insulin antibody assays simply provide a binary "present"/"absent" report. Some provide titres, but as assays are non standardised, and as many anti-insulin antibodies have no clinical significance, there is an unmet need to refine laboratory approaches to characterising such antibodies in order to yield clinically useful information. This report suggests such an approach using several different techniques to improve sensitivity and to identify those antibodies that may be clinically important and justify immunosuppression.
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This page is a summary of: Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography withex vivoinsulin exchange, Clinical Endocrinology, October 2016, Wiley,
DOI: 10.1111/cen.13179.
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