What is it about?
Because the sex of the disease-transmitting parent has been considered a potential factor that may influence differential expression of the disease, particularly the penetrance, we investigated the effect of maternal and paternal inheritance on phenotypic expression of psoriasis. We did not find that a sex-specific epigenetic inheritance pattern for psoriasis is a major contributing factor in family-specific risk in psoriasis. The presence of a parental effect on psoriasis transmission is but one of the issues that remain to be clarified.
Featured Image
Why is it important?
Results showed a high familial recurrence risk of psoriasis, but suggested a balanced parental transmission of the disease
Perspectives
Molecular investigations of candidate genes will help to better evaluate the true impact of parental transmission of psoriasis.
Dr Vito Di Lernia
Arcispedale S. Maria Nuova
Read the Original
This page is a summary of: Familial aggregation of moderate to severe plaque psoriasis, Clinical and Experimental Dermatology, August 2014, Wiley,
DOI: 10.1111/ced.12401.
You can read the full text:
Contributors
The following have contributed to this page
