What is it about?
SOX2 is overexpressed in ovarian cancer spheroid cells, which can maintain the cancer stem cell properties of spheroids, such as sphere formation capacity, cell proliferation, cell migration, cisplatin resistance, tumorigenicity and so on. In addition, SOX2 expression was closely associated with chemo-resistance and poor prognosis in ovarian cancer patients.
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Why is it important?
Our findings strongly suggest that SOX2 is required to maintain cancer stem cells in ovarian cancer.Targeting SOX2 in ovarian cancer may be therapeutically beneficial.
Perspectives
This article is of great significance on the treatment of ovarian cancer, I hope it can be seen by more readers.
Professor Zehua Wang
Huazhong University of Science and Technology
Read the Original
This page is a summary of: SOX2 is required to maintain cancer stem cells in ovarian cancer, Cancer Science, April 2017, Wiley,
DOI: 10.1111/cas.13186.
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