Olcegepant blocks neurogenic and non-neurogenic CGRPergic vasodepressor responses and facilitates noradrenergic vasopressor responses in pithed rats

What is it about?

Olcegepant is a CGRP receptor antagonist with antimigraine properties, but its potential cardiovascular risks remain unknown. This study in pithed rats shows that olcegepant (3000 µg kg-1, i.v.): (i) completely blocked the vasodepressor CGRPergic responses; and (ii) facilitated the vasopressor noradrenergic responses. These may result in a prohypertensive action.

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