What is it about?

The synthetic compounds were evaluated for their in vitro antibacterial activities, and as a result, the most prominent effects were observed for 3e and 4e. Especially, 3e was found to be quite active against all the tested strains with the MIC values ranging from 15 to 62 μg/mL, except P. aeruginosa. The results of the time-kill assay suggested that the compound of 3e completely inhibited the growth of both gram-negative bacteria, A. baumannii, and gram-positive bacteria, S. aureus. In addition, SEM analysis confirmed morphostructural damage of the bacteria. Our findings could be applicable for developing dual-targeting anticancer/antibacterial therapeutics.

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Why is it important?

The of developing dual-targeting anticancer/antibacterial therapeutics is necessary for cancer therapy.

Perspectives

Our findings could be applicable for developing dual-targeting anticancer/antibacterial therapeutics.

Effat Alizadeh
Tabriz University of Medical Sciences

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This page is a summary of: Study of the Cytotoxic and Bactericidal Effects of Sila-substituted Thioalkyne and Mercapto-thione Compounds based on 1,2,3-Triazole Scaffold, Basic & Clinical Pharmacology & Toxicology, July 2017, Wiley,
DOI: 10.1111/bcpt.12822.
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