What is it about?
We reviewed all the available data concerning the role of IGF1 and IGF1R in testicular differentiation and in Sertoli cell's proliferation among species. We found that it dyplays a relevant function both in non-mammalian and in mammalian species. This let hypothesize that the same mechanims already described in animals may occur also in humans.
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Why is it important?
The effects of IGF1 on human testicular function should be investigated in order to evaluate a possible future role in the management of male infertility,
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This page is a summary of: Effects of the insulin-like growth factor system on testicular differentiation and function: a review of the literature, Andrology, December 2017, Wiley,
DOI: 10.1111/andr.12444.
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