What is it about?
This research aimed to elucidate the TIME of SGC and its relationship with tumor mutation burden (TMB) and to explore the rationale for the applicability of immune check point inhibitors (ICPi).
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Photo by National Institute of Allergy and Infectious Diseases on Unsplash
Why is it important?
The TIME of adenoid cyctic carcinoma was the so-called immune desert type, which may explain the mechanisms of the poor response to ICPi in previous clinical trials. On the other hand, mucoepidermoid carcinoma (high-grade) was the immune-inflamed type, and this may support the rationale of ICPi for this pathological subtype.
Perspectives
The results indicated that the TIME of ACC was the so-called immune-desert type, whereas MEC high was the immune-inflamed type. These results may be useful in considering the potential application of ICPi to this rare malignancy.
Naomi Kiyota
Kobe University Hospital
Read the Original
This page is a summary of: Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer, Asia-Pacific Journal of Clinical Oncology, September 2024, Wiley,
DOI: 10.1111/ajco.14108.
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