What is it about?
FOXO3 is a well-known longevity gene. Here FOXO3 is found to interact directly with its 46 neighbouring genes on chromosome 1. Together they boost cell resilience. The "interactome" works as a "gene factory". The study also reports all genetic variants of FOXO3 that are sites of transcription factor binding. The variant most strongly associated with longevity is also associated with greater FOXO3 expression.
Featured Image
Why is it important?
The study reports the first "gene factory" for longevity. This is likely to confer healthy aging. The study represents a breakthrough in understanding the mechanisms by which FOXO3 confers its health benefits.
Perspectives
It was exciting to contribute to this amazing genomics breakthrough. The first author, Tim Donlon, is to be congratulated on his knowledge and skills in the genetics and genomics of aging and longevity.
Professor Brian J. Morris
University of Sydney
Read the Original
This page is a summary of:
FOXO3
longevity interactome on chromosome 6, Aging Cell, July 2017, Wiley,
DOI: 10.1111/acel.12625.
You can read the full text:
Contributors
The following have contributed to this page
