Ageing, vessel structure and clearance of waste from the brain

What is it about?

Development of cerebral amyloid angiopathy and Alzheimer's disease is associated with failure of elimination of amyloid‐β from the brain. This appears to occur in a brain region specific manner. In this study we use Western blotting, immunohistochemistry and quantitative electron microscopy to correlate alterations in the composition and ultrastructure of drainage pathways with the region specific occurance of cerebral amyloid angiopathy.

Featured Image

Why is it important?

The results of the study suggest that changes in vascular basement membranes and elimination of amyloid‐β from the brain with age differ between brain regions, in the mouse, in a manner that may help to explain the differential deposition of Aβ in the brain in AD and may facilitate development of improved therapeutic strategies to remove Aβ from the brain in AD.