What is it about?
We demonstrate that conditions encountered by enterohemorrhagic Escherichia coli (EHEC) in the human gastrointestinal tract, the primary niche of these pathogens, increase the amount of outer membrane vesicles (OMVs) produced by the bacteria and the amount of OMV-associated Shiga toxin, the major virulence factors of EHEC.
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Why is it important?
Our findings indicate that upregulation of OMV production by the human gastrointestinal milieu contributes to EHEC survival and adaptation within the host and establishig the infection. Moreover, the intrahost increase of OMV production and OMV-associated Stx2a may augment EHEC virulence.
Perspectives
This article supports the idea that not only the virulence potential of the pathogen itself, but also the conditions in the pathogen´s natural niche within the human host may substantially influence the final outcome of the infection.
Martina Bielaszewska
Institute for Hygiene, University of Muenster, Muenster, Germany
Read the Original
This page is a summary of: Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a and cytotoxicity in E
scherichia coli
O157:H7 and O104:H4, Environmental Microbiology Reports, July 2017, Wiley,
DOI: 10.1111/1758-2229.12562.
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