What is it about?
Hypertension is a global health problem that will affect about one-third of the world’s population by 2025. Renovascular (related to kidney diseases) hypertension is one of the major types of secondary hypertension. apelin is an endogenous peptide that decreases blood pressure and is one of the most important hormones in cardiovascular homeostasis. The purpose of this study was to evaluate the interaction between the apelin/APJ and opioid/OPR systems regarding both cardiac and vascular actions of apelin in a chronic renovascular hypertension model.
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Why is it important?
This study helped to assess the potential cumulative therapeutic action of apelin and opioids in the management of cardiovascular complications because opioids are currently used in the management of myocardial infarction (MI) and stroke, which are complications of hypertension and apelin has been introduced as a potential therapeutic agent in management of these complications.
Perspectives
I hope this article finally help to the treatment of hypertension, that is a global health problem.
Dr Hamid Najafipour
Kerman University of Medical Sciences
Read the Original
This page is a summary of: Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension, Clinical and Experimental Pharmacology and Physiology, November 2017, Wiley,
DOI: 10.1111/1440-1681.12860.
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