What is it about?

It is not easy to measure ALS gene expression, since ALS takes place in neurons. In this study, we identified genes associated with aberrant gene expression with re-analyzing published skin gene expression of patients.

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Why is it important?

We have identified limited number of genes associated with aberrant gene expression by integration of two skin gene expression analysis.

Perspectives

I have used PCA based unsupervised FE to various biological problems. In this paper, I have demonstrated that this methodology can identify aberrant gene expression even if they are very slight.

Professor Y-h. Taguchi
Chuo Daigaku

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This page is a summary of: Heuristic principal component analysis-based unsupervised feature extraction and its application to gene expression analysis of amyotrophic lateral sclerosis data sets, August 2015, Institute of Electrical & Electronics Engineers (IEEE),
DOI: 10.1109/cibcb.2015.7300274.
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