What is it about?
A brief review on direct methods in protein crystallography is given. Examples are also given on difficult SAD phasing, model building and low-resolution phase extension.
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Why is it important?
A direct method has been incorporated in an iterative dual-space phasing and model building framework. The direct method is acting as a phase restrain procedure in the reciprocal space. This makes the iteration particularly powerful in difficult SAD phasing, model completion and low-resolution phase extension.
Perspectives
The method may be useful in combination with the oversampling procedure in single-particle CDI (coherent diffraction imaging) using XFEL (X-ray free electron laser) light sources.
Professor Haifu Fan
Institute of Physics, CAS, China
Read the Original
This page is a summary of: Applications of direct methods in protein crystallography for dealing with diffraction data down to 5 Å resolution, Acta Crystallographica Section A Foundations and Advances, March 2014, International Union of Crystallography,
DOI: 10.1107/s2053273313034864.
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