Safe Shipping of Biomacromolecular Samples: Guidelines and Recipes for Successful Experiments

What is it about?

The article provides guidelines for shipping biomacromolecular samples to large facilities for structural biology studies. It discusses general considerations and specific tips for shipping samples for solution-based and cryogenic-based techniques. The aim is to ensure that the time and energy invested in sample preparation is not lost due to shipping logistics. The article emphasizes the importance of clear labeling, following safety procedures, and consulting with local contacts at the facility.

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Photo by National Institute of Allergy and Infectious Diseases on Unsplash

Photo by National Institute of Allergy and Infectious Diseases on Unsplash

Why is it important?

This research is important because it provides guidance and discusses general considerations for shipping biomacromolecular samples to remote data-collection resources. These samples are often expensive, time-consuming, and resource-intensive to produce, and any damage or delay in shipping can result in significant loss of time, energy, and money. This article aims to help researchers avoid such logistical issues and ensure that their samples arrive safely and can be measured accurately. Key Takeaways: 1. Shipping biomacromolecular samples requires careful consideration and planning to ensure their safe arrival at the facility. 2. Researchers should consult the specific standard operating procedures (SOPs) and requirements of the facility they are using. 3. Secondary containment and clear labeling are universally applicable principles for shipping biomacromolecular samples. 4. When shipping solution-based samples for small-angle X-ray scattering (SAXS), it is important to follow stability characterization steps and to clarify the necessary format with the local contact. 5. When shipping samples for crystallization, it is important to include all components that keep the sample stable, but to keep buffer, salt, and glycerol concentrations as low as possible. The best buffer is the simplest formulation possible that maintains solubility, homogeneity, stability, and activity of the sample.