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The Pif1 family DNA helicase Pfh1 plays a dual role in promoting replication fork termination. First, it facilitates replication past DNA–protein barriers, and second, it promotes the merging of replication forks. A failure of these processes in Pfh1-deficient cells results in aberrant chromosome segregation and increased genome instability.
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This page is a summary of: The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability, Genes & Development, March 2012, Cold Spring Harbor Laboratory Press,
DOI: 10.1101/gad.184663.111.
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