Use replication timing data from multiple cell types to annotate human genome

What is it about?

Our work is similar to chromatin states, which use histone mark ChIP-seq data from multiple cell types to annotate the human genome, Here, we instead using replication timing data as the source of annotation.

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Why is it important?

Our work provides an alternative way to annotate the human genome, especially on the non-coding part. Since replication timing is important mechanism, we believe RT states provide unique perspective on the functional potential of different regions in the genome.