The antiviral potential of the antiandrogen enzalutamide and the viral-androgen interplay in seasonal coronaviruses

What is it about?

New study suggests that the antiandrogen enzalutamide could be effective against human coronaviruses NL63 and 229E. It was found that enzalutamide can reduce the entry and replication of these viruses in cells, indicating a potential mechanism. However, enzalutamide was not effective against the OC43 coronavirus. Further analysis showed that androgen signaling plays a significant role in the interaction between viruses and host cells. These findings could lead to the development of new antiviral treatments for coronaviruses. Further research is needed to fully understand the potential of enzalutamide in combating these viruses.

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