Common genetic variation drives molecular heterogeneity in human iPSCs

What is it about?

This study showcases the hipsci project. It deals with characterisation of a large panel of cells obtained from healthy volunteers (blood donors) integrating data from their DNA, RNA, Proteins and Cell behaviour as analysed from microscopic images. As up to 3 clones are available for each donor, this approach allows to start asking questions about how different are cells obtained from the same individual, and how much of this difference can be down to the genetics.

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Why is it important?

www.hipsci.org the project has generated hundreds of cell lines that are available together with data and tools for the scientific community to build upon.

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