What is it about?
Feedback inhibition of the N-acetylglutamate kinase activity was shown both in C. glutamicum and in recombinant E. coli argB auxotrophic strains. Extracts of E. coli cells carrying cloned corynebacterial DNA display an ornithine acetyltransferase activity (encoded by argJ), which alleviates the acetylornithinase (encoded by argE) deficiency.
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Why is it important?
This study provides a valuable information on arginine biosynthesis and regulation of corresponding genes in Corynebacterium glutamicum, a bacterium of industrial importance for production of L-amino acids.
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This page is a summary of: Genes and enzymes of the acetyl cycle of arginine biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early steps of the arginine pathway, Microbiology, January 1996, Society for General Microbiology,
DOI: 10.1099/13500872-142-1-99.
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