Gain restoration after gentamicin

What is it about?

This study included 20 patients with unilateral Menière's disease refractory to medical therapy for at least 1 year and treated with an on-demand intratympanic gentamicin protocol. Audiometry, caloric testing, and a vHIT before beginning the protocol were performed. Patients underwent weekly vHIT assessments until a significant gain reduction was observed. Subsequently, we performed vHIT tests 1 month after the therapy completion, and then every 3 months for at least 1 year. RESULTS: Complete vertigo control (class A) was achieved in 14 patients at the 12-month follow-up assessment. We observed a significant reduction in VOR gain values at the 3-week follow-up assessment. We found a significant correlation between the 1-month posttreatment ipsilateral hVOR gain and the rate of vertigo recurrence after the first IT gentamicin treatment (p = 0.012; r = 0.400). At the mid-term assessment, 10 patients exhibited significant partial recovery of the hVOR gain.

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Why is it important?

The delayed effect of intratympanic gentamicin and the subsequent gain restoration are factors that may influence the patients' outcome. We observed a better prognosis in patients without gain recovery that those who showed a gain restoration