Accuracy of a nomogram for vancomycin in patients who are at risk for augmented renal clearance.

What is it about?

In patients with augmented renal clearance (ARC), individualized dosing regimens are required to achieve the target trough concentration. In this study, we try to evaluate the validity of dose-adjustment regimen of vancomycin (VCM) in ARC patients.

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Why is it important?

We believe that our study makes a significant contribution to the literature because the superiority of this validated nomogram over existing regimens in avoiding toxic concentrations was demonstrated, although the nomogram was challenged by a lack of accuracy in achieving target trough concentrations. However, the nomogram accuracy could be improved by classifying patients based on age, and the present findings indicate the benefits of the nomogram in facilitating the avoidance of subtherapeutic concentrations of VCM in patients who are at risk for augmented renal clearance.

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