What is it about?
We retrospectively reviewed the charts of patients with POLF admitted to the intensive care unit who underwent TPE between November 2010 and March 2017. POLF was defined as the presence of persistent hyperbilirubinemia. Data on patient demographics, Glasgow Coma Scale score, platelet count, prothrombin time, and serum total bilirubin level were collected, and their Sequential Organ Failure Assessment scores were calculated. The lengths of postoperative hospital stays, lengths of post-TPE hospital stays, and patient outcomes were also analyzed.
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Why is it important?
Although TPE may improve laboratory values in patients with POLF, the current study suggests that it has no survival benefit.
Perspectives
Our findings revealing the extremely poor outcomes of patients with POLF treated with TPE suggest that TPE should be limited to specific cases because of its futility and that the number of TPE sessions should be restricted to time-limited trials.
Dr Yoshiro Kobe
Chiba Emergency Medical Center
Read the Original
This page is a summary of: Effects of therapeutic plasma exchange on survival in patients with postoperative liver failure: a retrospective single-center study, Emergency and Critical Care Medicine, November 2021, Wolters Kluwer Health,
DOI: 10.1097/ec9.0000000000000015.
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