Phosphatidylglycerols are novel lipids dysregulated in obesity

What is it about?

At the interface of nutritional environment and host immunity, gut microbes are now considered important players in diseases, and likely to regulate metabolism through the release of molecules with activity in the host. By assessing gene sequences in the metagenome, a complete view of the diversity of microbes communities that live in the gut can be assessed. This study combines serum lipidomics and metagenome analysis in patients with obesity to identify lipids species that might be linked to gut dysbiosis, and focus on phosphatidylglycerols (PGs) that are mostly associated with decreased gut microbiota richness in patients and mice models with obesity. We describe a novel regulatory loop in which gut dysbiosis-related inflammation promotes PG synthesis, which in turn regulates adipose tissue lipid mobilization and expansion capacity.

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