Bone marrow cell response after injury and during early stage of regeneration is independent of the tissue‐of‐injury in 2 injury models

What is it about?

Several investigations suggest that the different cell types of bone marrow help tissues to regenerate. However, this process it is still not completely understood. In this study, we performed different experiments to understand how the different cellular populations of the bone marrow behave in response to the specific lesion (injury in skin and muscle tissues or injury in skin, muscle, and bone) and if their behavior change during the initial times of the tissue regeneration. We also examined post-injury, the level of certain molecules in the blood, known to influence the activity of the bone marrow cells. For the first time, we show that when a tissue is injured, there is a highly coordinated reorganization of the bone marrow cell populations that occur in a time-dependent manner. In addition, this response is identical whether the injury is inflicted solely to skin and muscle, or skin, muscle and bone. In another hand in the blood, we found differences in the levels of some molecules that are relevant in tissue regeneration. Overall, this study contributes better understand the role of bone marrow in tissue regeneration and provides new insights to the development of new alternative clinical approaches and injury-specific therapies.

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