Sustained spatiotemporal release of TGF-β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns

What is it about?

Defects of cartilage, the tissue covering the ends of bones do not heal. This study investigates the effects of TGF-β, a growth factor stimulating the growth of cartilage, under conditions of very early cartilage repair in a large animal model of a cartilage defect. The results show significant effects of TGF-β on the early cartilage repair by enhancing cell growth and production of the extracellular matrix. These findings are important because they identify a mechanism by which TGF-β1 modulates early cartilage repair (chondrogenesis), highlighting the pivotal role of TGF-β during early cartilage repair.

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