Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

What is it about?

All Cells interact with the so called extracellular matrix and this is an important process in normal but even more in pathological conditions, particularly in fibrosis and cancer. Two of the key proteins involved in driving this cell-matrix interactions are the enzyme transglutaminase 2 (TG2) and fibronectin (FN). So far no clear knowledge on how the two protein interact is available but this is a relevant scientific question as a precise definition of how they interact with each other could provide a tool to design novel potential therapeutic applications._x000D_ In order to understand how the two proteins interact we produced several smaller variants of the Fibronecting and test if they could bind to TG2. At the end we found, the first time, that all the important functions on this interaction were just mediated by a small fragment of Fibronectin.

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