What is it about?
Noxa is an apoptotic protein as it translocates from cytosol to mitochondria and binds with an antiapoptotic protein Mcl1 leading to the degradation of the latter. This work shows that Helicobacter pylori infection induce Noxa phosphorylation at Ser 13 residue in gastric epithelial cells which prevents Noxa from being translocated to the nucleus and therefore, prevents Noxa-mediated cell death.
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Why is it important?
We establish an unique event induced by Helicobacter pylori that promotes gastric cancer progression
Perspectives
This publication is very special to me since it is my first publication as a corresponding author.
Dr. Asima Bhattacharyya
National Institute of Science Education and Research (NISER), HBNI
Read the Original
This page is a summary of: Regulation of Noxa-mediated apoptosis in Helicobacter pylori–infected gastric epithelial cells, The FASEB Journal, March 2015, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.14-257501.
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