Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials

  • Monica S M Persson, Joanne Stocks, Gyula Varadi, Mohammad Hashem Hashempur, Marienke van Middelkoop, Sita Bierma-Zeinstra, David A Walsh, Michael Doherty, Weiya Zhang
  • Rheumatology, April 2020, Oxford University Press (OUP)
  • DOI: 10.1093/rheumatology/keaa113

Predicting the response of pain relief drugs when applied to osteoarthritis patients’ skin

Photo by Clarissa Watson on Unsplash

Photo by Clarissa Watson on Unsplash

What is it about?

By combining the individual patient data from different clinical trials of topical non-steroidal anti-inflammatory drugs (NSAIDS), this study aims to identify factors which may be able to help predict which patients will respond best to which treatment.

Why is it important?

Patient-level predictors of treatment response could improve clinical decision-making by helping to guide the optimum treatment selection for individual patients, at the time of their assessment. Our analysis found that topical NSAIDs are effective for osteoarthritis pain relief and that a greater overall pain relief was found individuals who had the most pain before they started using the drug.

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The following have contributed to this page: Dr Joanne Stocks