What is it about?
Inflammation is a hallmark of chronic kidney disease (CKD) and stimulates glomerular expression of vascular adhesion molecules (VCAMs). We investigated in a general population whether estimated glomerular filtration rate (eGFR) is associated with circulating adhesion molecules, inflammation markers or both.
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Why is it important?
In a general population, eGFR is inversely associated with circulating adhesion molecules VCAM-1 and MCP-1 and several inflammation markers, but inflammation markers, in particular TNF-R1 and TNF-α, identify patients with eGFR <60 mL/min/1.73 m2 more accurately.
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This page is a summary of: Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population, Nephrology Dialysis Transplantation, August 2017, Oxford University Press (OUP),
DOI: 10.1093/ndt/gfx256.
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