What is it about?
1. At early stage of hypoxia, urinary albumin excretion and podocyte shedding was enhanced in association with mesangiolysis with loss of glomerular endothelial cells. 2. At late stage of hypoxia, nodular or segmental sclerosis developed on the basis of mesangiolysis with low density of podocyte under the influence of high hematocrit.
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Why is it important?
This study suggests that chronic hypoxia may be one of the major pathogenic factors in the development of diabetic nephropathy.
Perspectives
Complication of hypoxemic condition such as heart failure, sleep apnea and chronic obstructive lung disease may be considered an exacerbating factor in care of diabetic patients. Also, high altitude residence may aggravate diabetic nephropathy.
NAOKI TAKAHASHI
Fukui Daigaku
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This page is a summary of: Chronic hypoxia exacerbates diabetic glomerulosclerosis through mesangiolysis and podocyte injury in db/db mice, Nephrology Dialysis Transplantation, June 2020, Oxford University Press (OUP),
DOI: 10.1093/ndt/gfaa074.
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