‘Z-DNA like’ fragments in RNA: a recurring structural motif with implications for folding, RNA/protein recognition and immune response

What is it about?

DNA and RNA are structurally different. We show in many RNA structures a conformational motif that has been found first in DNA, and we connect it to RNA structure and biological functions.

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Why is it important?

This paper addresses the much-overlooked occurrence of left-handed “Z-DNA like” conformations within RNA. A direct role of these Z-like motifs is proposed in folding of large RNA assemblies and in the RNA/protein recognition. In particular, they seem to be involved in significant immunology processes related to self/non-self discrimination.