What is it about?
The rhp9 gene (now called Crb2) is required for the G2/M DNA damage checkpoint. It is a signal transduction molecule required to signal the presence of DNA damage and arrest the cell cycle to allow time for repair. The Rhp9/Crb2 protein contains two BRCT domains, that we subsequently analysed in more detail, both structurally and functionally (Kilkenney et al, 2008).
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Why is it important?
This is the S. pombe homologue of the human protein 53BP1. As such it is a good model for the study of this family of proteins, as many of its interactions and functions are conserved.
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This page is a summary of: Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint, Nucleic Acids Research, June 1997, Oxford University Press (OUP),
DOI: 10.1093/nar/25.11.2138.
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