What is it about?
Although ELAGIGILTV-specific CD8+ T cells from different donors initially possessed a naive phenotype, after antigen-induced in vitro expansion two distinct phenotypes correlating with cell proliferation rate emerged in the different donors.
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Why is it important?
Those cultures achieving fewer cumulative population doublings (CPDs) were cytotoxic and displayed a CD45RA+CCR7- phenotype. In contrast, cultures reaching higher CPDs were non-cytotoxic T cells with a CD45RA-CCR7- phenotype. The generation of larger numbers of ELAGIGILTV-specific CD8+ T cells correlates negatively with the acquisition of a CD45RA+CCR7- phenotype and cytotoxic capacity.
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This page is a summary of: Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells, International Immunology, December 2008, Oxford University Press (OUP),
DOI: 10.1093/intimm/dxn123.
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