What is it about?
We demonstrated that human serum albumin binds toxin Clostridioides difficile toxin A and toxin B, blocking their cellular (enterocytes) damage. We demonstrated that a pre-treatment with human serum albumin in animals exposed to C. difficile toxin B decreased mortality.
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Why is it important?
It provides solid in vitro and in vivo data on the protective potential of human serum albumin towards C. difficile
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This page is a summary of: Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication, The Journal of Infectious Diseases, June 2018, Oxford University Press (OUP),
DOI: 10.1093/infdis/jiy338.
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